Doctor Discovery: Identifying Hidden KOLs through Publications and Clinical Trials
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Doctor Discovery: Identifying Hidden KOLs through Publications and Clinical Trials

Key Opinion Leaders (KOLs) aren't always on speaker bureaus. Many publish quietly or run niche studies. This piece explains how AI agents can mine PubMed a

December 3, 2025NeoPharma Research Team

Doctor Discovery: Identifying Hidden KOLs through Publications and Clinical Trials

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The Key Opinion Leader (KOL) marketing market is projected to witness significant growth, with the Rest of MEA market expected to grow at a CAGR of 26.8% during the forecast period, reaching a market size of USD xx million in 2024 according to Key Opinion Leader (KOL) Marketing market report. This growth underscores the importance of identifying and engaging with influential healthcare professionals. Pharmaceutical sales representatives and marketing managers are recognizing the value of KOLs in shaping medical opinions and driving sales. This article will explore the current state of KOL identification, the challenges associated with it, and provide actionable insights on how to leverage publications and clinical trials to discover hidden KOLs.

The ability to identify and engage with the right KOLs is crucial for pharmaceutical companies to stay ahead of the competition. With over 21,000+ reports across sectors providing context for expert influence, thematic relevance, and sector-specific insights according to KOL Research Services & KOL Insights - Mordor Intelligence, the task of identifying hidden KOLs can be daunting. However, by leveraging AI agents to mine PubMed and trial registries, pharmaceutical sales professionals can uncover emerging KOLs before their competitors. This article will provide a strategic approach to identifying hidden KOLs, enhancing HCP engagement, and driving sales performance.

The Current State

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The KOL marketing landscape is evolving, with pharmaceutical companies shifting from traditional approaches to more targeted and data-driven strategies. A top 10 pharma company used KOL mapping to exceed conference engagement goals according to hcp-and-kol-mapping-a-comprehensive-guide-for-pharma-teams-u-s, demonstrating the effectiveness of this approach. Another large pharmaceutical company transitioned from a purely "national KOL" strategy to include Community Opinion Leaders, using mapping to adjust its approach according to hcp-and-kol-mapping-a-comprehensive-guide-for-pharma-teams-u-s. These examples illustrate the importance of adapting to changing market dynamics and leveraging data to inform KOL engagement strategies.

The use of advanced analytics is also becoming increasingly important in KOL engagement. A global biotech improved KOL engagement with advanced analytics according to A Global Biotech Improves KOL Engagement With Advanced Analytics, demonstrating the value of data-driven approaches. Furthermore, the France Key Opinion Leader (KOL) Marketing market is projected to witness growth at a CAGR of 25.8% during the forecast period, with a market size of USD xx million in 2024 according to Key Opinion Leader (KOL) Marketing market report. This growth highlights the potential for pharmaceutical companies to leverage KOLs in this market.

The current state of KOL identification is also influenced by the preferences of healthcare professionals (HCPs). HCPs born before 1981 consistently rate live, in-person KOL presentations highly, whereas younger HCPs (≥1981) show significantly less interest in virtual KOL programs and KOL videos according to KOL Mapping: A Pharma Playbook with Methods & Templates. This shift in preferences underscores the need for pharmaceutical companies to adapt their KOL engagement strategies to meet the evolving needs of HCPs.

The Challenge

Identifying and engaging with the right KOLs is a challenging task, with many pharmaceutical companies lacking an objective-driven approach to KOL engagement. This can result in a one-size-fits-all marketing strategy, which may not effectively reach or engage the target audience according to A Global Biotech Improves KOL Engagement With Advanced Analytics. The task of identifying hidden KOLs is further complicated by the vast amount of data available, making it difficult to surface emerging experts. Additionally, the lack of a standardized approach to KOL identification and engagement can lead to inconsistent results and a lack of ROI.

The challenge of identifying hidden KOLs is also exacerbated by the complexity of the healthcare landscape. With multiple stakeholders involved in the decision-making process, it can be difficult to determine who the most influential KOLs are. Furthermore, the rise of digital channels has created new opportunities for KOLs to share their opinions and expertise, making it harder to track and measure their influence. A pharmaceutical company entering a new therapeutic area may need a sustainable expert support system, and may even decide against launching a drug if they cannot identify the right KOLs to support it according to Smart solutions Medical Affairs & Pharma Marketing.

The lack of predictive analytics and AI-driven approaches to KOL identification is also a significant challenge. While some companies are using advanced analytics to improve KOL engagement, many are still relying on traditional methods, such as manual research and personal networks. This can lead to a lack of objectivity and consistency in KOL identification, making it difficult to scale and replicate successful engagement strategies.

What's Working

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Despite the challenges, there are several solutions and best practices that are working for pharmaceutical companies. One approach is to use AI agents to mine PubMed and trial registries, uncovering emerging KOLs and identifying patterns and trends in their research and publications. This can help pharmaceutical companies to identify hidden KOLs before their competitors and engage with them in a more targeted and effective way.

Another approach is to use KOL mapping to identify and prioritize KOLs based on their influence, relevance, and engagement. This can help pharmaceutical companies to develop a more objective-driven approach to KOL engagement, focusing on the KOLs who are most likely to drive sales and shape medical opinions. A top 10 pharma company used KOL mapping to exceed conference engagement goals according to hcp-and-kol-mapping-a-comprehensive-guide-for-pharma-teams-u-s, demonstrating the effectiveness of this approach.

The use of digital channels is also becoming increasingly important in KOL engagement. With the rise of social media and online platforms, KOLs are now able to share their opinions and expertise with a wider audience, creating new opportunities for pharmaceutical companies to engage with them. Digital presence and omnichannel strategies are becoming increasingly important factors in the dissemination of science by medical personnel according to Fall 2024 - MSL Journal, highlighting the need for pharmaceutical companies to adapt their KOL engagement strategies to meet the evolving needs of HCPs.

The Road Ahead

The future of KOL identification and engagement is likely to be shaped by the increasing use of AI and predictive analytics. The next frontier is predictive KOL analysis, using AI to forecast which emerging experts are likely to become influential according to KOL Mapping Guide: Methods, Data & Analysis Explained. This will enable pharmaceutical companies to identify and engage with KOLs earlier, driving sales and shaping medical opinions.

The use of AI and machine learning will also enable pharmaceutical companies to analyze large amounts of data, identifying patterns and trends in KOL research and publications. This will help to surface emerging KOLs and identify areas of expertise, enabling pharmaceutical companies to develop more targeted and effective KOL engagement strategies. Accelerating new drug indication launch through strategic thought leader engagement will also become increasingly important according to Industry Report on KOL Identification, Planning and Engagement - H1, highlighting the need for pharmaceutical companies to adapt their KOL engagement strategies to meet the evolving needs of HCPs.

Action Items

To identify and engage with hidden KOLs, pharmaceutical sales representatives and marketing managers should consider the following key insights:

* Leverage AI agents to mine PubMed and trial registries, uncovering emerging KOLs and identifying patterns and trends in their research and publications

* Use KOL mapping to identify and prioritize KOLs based on their influence, relevance, and engagement

* Develop a digital presence and omnichannel strategy to engage with KOLs and HCPs

Here are three specific next steps to take:

1. Conduct a thorough analysis of current KOL engagement strategies, identifying areas for improvement and opportunities to leverage AI and predictive analytics

2. Develop a KOL mapping framework, prioritizing KOLs based on their influence, relevance, and engagement

3. Establish a digital presence and omnichannel strategy, engaging with KOLs and HCPs through social media, online platforms, and other digital channels

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